Ointment, as a dosage form that acts directly on the skin, requires the integration of knowledge from multiple disciplines such as pharmacy and dermatology in its research and development, and the application of cutting-edge technologies to ensure the safety, efficacy and stability of the drug. The following focuses on the research and development of ointment drugs, introducing key technologies from aspects such as the loading of active ingredients, prescription design, preparation process, and quality inspection. ​
I. Active Ingredient Loading Technology

1. Nanotechnology

Nanotechnology significantly enhances the dissolution rate and skin penetration ability of drugs by reducing the particle size of drugs and increasing the specific surface area of active ingredients. R&d personnel use technologies such as nano-precipitation and emulsification to prepare nano-scale drug carriers, such as nano-liposomes and nano-emulsions. Nano-liposomes, with their phospholipid bilayer structure, encapsulate hydrophilic or hydrophobic drugs, not only enhancing drug stability but also enabling targeted drug delivery and reducing toxic and side effects on normal tissues. ​

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Description Description

Description Description

he Transdermal drug delivery system (TDDs) refers to a drug delivery route in which drugs are absorbed through the skin into the human bloodstream and reach an effective blood drug concentration to achieve disease prevention or treatment. It is the third major drug delivery system after oral administration and injection administration. It has the advantages of good therapeutic effect and self-medication, and to a certain extent, it solves the problems such as first-pass metabolism, peak-valley phenomenon and poor compliance of traditional drug administration methods.

There are mainly three types of modern transdermal patches: gel patches (Cataplasm), hot melt patches (Tape), and solvent patches (Patch). At present, Gaomai Pharmaceutical has established a transdermal patch technology platform, focusing on the development of transdermal drug delivery preparations for chemical drugs and traditional Chinese medicine, and providing one-stop solutions from research and development to application. The patch laboratory is equipped with advanced formulation research and development equipment, including planetary mixers, high-speed dispersion homogenizers, small-scale experimental...